Paresthesia, characterized by an uncomfortable “pins and needles” sensation, can arise from various causes including nerve, spinal cord, or brain irritation or damage. This condition can be temporary or permanent, often exacerbated by the compression of both the nerve and the arteries supplying it, cutting off essential oxygen and glucose. Pain often intensifies at night, potentially due to hormonal fluctuations; specifically, the dip in anti-inflammatory cortisol levels during nighttime. This may also be influenced by the body’s circadian rhythm.

Peripheral Neuropathy (PN) can manifest as pain, numbness, tingling, or burning sensations, primarily in the extremities. While PN might subside after cancer treatment as nerves regenerate, it can persist for years in some cases. To manage the widespread pain, consulting with healthcare providers is crucial.

The peripheral nerves, an extension of the central nervous system, are prone to neuropathies that can range from mild to severe, impacting muscle strength and sensation. The resultant neuropathic pain, often chronic and debilitating, necessitates coping strategies, such as Cognitive Behavioral Therapy (CBT), for effective management.

Differentiating between nociceptive (body) pain and neuropathic (nerve) pain is essential for treatment, as they originate from distinct sources and present with varying symptoms. Moreover, the sensation of numbness or tingling itself can indicate nerve function issues, requiring medical attention to identify and address the underlying cause.

For further information on these conditions and their management, resources are available from reputable institutions:
University of Rochester,
Harvard Health,
OHSU Brain Institute, and
Columbia Neurosurgery.