Dementia with Lewy Bodies (DLB) is a form of progressive dementia characterized by the decay of brain tissues and the buildup of abnormal protein particles known as Lewy bodies within the brain tissue. These Lewy bodies are also found in individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD), indicating a shared pathological feature among these conditions.

DLB often begins with changes in thinking and behavior, followed by the emergence of movement problems similar to those present in classical Parkinson’s disease. This includes rigid muscles, slowed movement, walking difficulties, and tremors. Visual hallucinations and fluctuations in alertness and attention are also common symptoms.

While the exact cause of the protein accumulation is not fully understood, Lewy bodies interfere significantly with neuronal function, leading to the symptoms observed in DLB. In addition to these cognitive and motor symptoms, Parkinsonian features when Lewy bodies affect the brain stem can lead to a diagnosis of Parkinson’s disease. However, when they accumulate in other areas of the brain, they lead to DLB.

The risk factors for developing DLB include advanced age, and there is also a hereditary component to the disease. It is the second most common cause of dementia after Alzheimer’s disease and is estimated to affect 1.4 million individuals and their families in the United States alone.

Research continues to explore the causes of DLB, the risk factors, and the mechanisms behind the buildup of Lewy bodies. In the meantime, providing care and support for those affected is paramount.

For more information on Lewy body dementias, you can visit the Memory and Aging Center. Additionally, resources such as the Health Encyclopedia – University of Rochester, Mayo Clinic, Harvard Health, Baylor Medicine – Baylor College of Medicine, and educational materials such as A Patient’s Guide to Dementia with Lewy Body Disease and information provided by brain.northwestern.edu are valuable for patients and caregivers seeking to understand this condition.